Award details

Biosynthesis and assembly of the African swine fever virus membrane

Reference	BBS/E/I/00000018
Principal Investigator / Supervisor	Professor Tom Wileman
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	9,631
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1997
Duration	6 months

Abstract

African Swine Fever (ASF) virus is a large icosahedral enveloped DNA virus that causes a fatal haemorrhagic disease of domestic pigs. The virus is 200nm in diameter with a central nucleoprotein core surrounded by protein matrix, lipid envelopes and capsid. We are studying the cell biological mechanisms of recruitment of inner lipid envelopes of the virus and have shown that they formed from membrane cisternae of the endoplasmic reticulum (ER). During assembly of the virus membrane cisternae of the ER are bent through an ordered series of structural intermediates which eventually form icosahedral particles. A family of proteins encoded by ASF virus have C-terminal ER retention sequences. These may be involved in recruiting the ER cisternae during virus assembly.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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