Award details

502: Interplay between plant defence and virul counter-defence

Reference	BBS/E/H/00YH0221
Principal Investigator / Supervisor	Professor Yiguo Hong
Co-Investigators / Co-Supervisors
Institution	University of Warwick
Department	Warwick HRI
Funding type	Research
Value (£)	150,000
Status	Completed
Type	Institute Project
Start date	01/04/2005
End date	31/03/2006
Duration	12 months

Abstract

"Plants have evolved pathogen-inducible resistance mechanisms, the hypersensitive response (HR) and RNA silencing, against infection. In order to withstand host defence responses, pathogens often encode defence-suppressing proteins. The HR defense is elicited by pathogen-specific avirulence determinants including many plant viral proteins. RNA silencing is a sequence specific RNA degradation mechanism operating across kingdoms. In plants, RNA silencing is non cell- autonomous and plays a key role in antiviral defence. In return, viruses have evolved to produce proteins capable of inhibiting RNA silencing, or getaway from RNA silencing defence without deploying protein-mediated silencing suppression. To further our understanding of plant defence and viral counter- defence, I propose in this project to investigate molecular and cellular events in viral protein-mediated HR and identify novel HR suppressors encoded by a plant virus. I also propose to investigate cell-to-cell spread of RNA silencing and RNA- mediated antiRNA silencing in plants. The proposed works are highly relevant to the research areas Pathogenesis, Epigenetics, Communication and Signalling in the Integrative Biology priority area, and to Understanding Diseases in the Sustainable Agriculture priority area in the BBSRC Strategic Plan 2003-2008. They fit with the Warwick HRIs Science Mission to provide academic excellence in plant and microbial sciences and its application to horticulture, crops and the environment. Dissection of plant defence and pathogen counter-defence mechanisms will help to develop novel strategies to control plant diseases. This project is both complementary to and synergistic with Warwick HRI other research activities related to host-pathogen gene-for-gene interactions in crops."

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search