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Award details
605: Detecting Genomic Mosaicism Using Phylogenomics
Reference
BBS/E/H/00RA0272
Principal Investigator / Supervisor
Professor Robin Allaby
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Warwick HRI
Funding type
Research
Value (£)
282,559
Status
Completed
Type
Institute Project
Start date
01/04/2006
End date
31/03/2007
Duration
12 months
Abstract
The aim of this project is to develop tools for the high throughput analysis of genomic mosaicism using genome wide automated phylogenetic approaches. A novel aspect of phylogenomics under development tracks the reticulate evolutionary history of genes through a high throughput automated approach. Fragments of sequence, which may originate from anywhere in the genome, are identified that are phylogenetically closer to sequences than the expected orthologs. The methodology requires that many (thousands) robust phylogenetic analyses are carried out and interpreted in automation. This approach has already identified remarkable patterns of mosaicism in the GPCR gene family that link to unexpected but real function.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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