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605: Detecting Genomic Mosaicism Using Phylogenomics

ReferenceBBS/E/H/00RA0272
Principal Investigator / Supervisor Professor Robin Allaby
Co-Investigators /
Co-Supervisors
Institution University of Warwick
DepartmentWarwick HRI
Funding typeResearch
Value (£) 282,559
StatusCompleted
TypeInstitute Project
Start date 01/04/2006
End date 31/03/2007
Duration12 months

Abstract

The aim of this project is to develop tools for the high throughput analysis of genomic mosaicism using genome wide automated phylogenetic approaches. A novel aspect of phylogenomics under development tracks the reticulate evolutionary history of genes through a high throughput automated approach. Fragments of sequence, which may originate from anywhere in the genome, are identified that are phylogenetically closer to sequences than the expected orthologs. The methodology requires that many (thousands) robust phylogenetic analyses are carried out and interpreted in automation. This approach has already identified remarkable patterns of mosaicism in the GPCR gene family that link to unexpected but real function.

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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