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601: Understanding the receptor-mediated disease resistance and susceptibility using multidisciplinary approach

Reference	BBS/E/H/00MT0235
Principal Investigator / Supervisor	Professor Mahmut Tör
Co-Investigators / Co-Supervisors
Institution	University of Warwick
Department	Warwick HRI
Funding type	Research
Value (£)	340,374
Status	Completed
Type	Institute Project
Start date	01/04/2005
End date	31/03/2007
Duration	24 months

Abstract

The ability of plants to recognise pathogen-derived molecules and activate the defence mechanisms is often associated with disease resistance (R) proteins. Extracellular and intracellular race specific effector molecules (encoded by Avr genes) can be detected directly or indirectly, by structurally different classes of R proteins. Receptor-like kinases (RLKs) and receptor-like proteins (RLPs) have extracellular LRR domains and a transmembrane spanning region, and have been suggested to recognize pathogen-derived molecules outside of the membrane. On the other hand, cytoplasmically localized NB-LRR proteins have been shown to interact directly or indirectly with effector molecules within the cell. Arabidopsis has 57 RLP- and more than 200 RLK-encoding genes. Using the T-DNA insertion lines corresponding to these genes, our long term aims are to understand; a) the events that take place upstream of the receptor like proteins (interaction of ligand/receptor), b) the transmission ofthe signal from the extracellular space into intracellular space (endocytosis/conformational changes), c) downstream signaling components (co-expression network) and d) the link between recognition at the extracellular space and the cytoplasmic receptors such as NB-LRR genes. We want to investigate these events by using genetics, pathology, molecular biology techniques, biochemistry and proteomics. We will be carrying out research to determine if any RLPs/RLKs are activated or suppressed in Arabidopsis-H. parasitica interaction leading to resistance or susceptibility.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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