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402b: Genomics of Xenorhabdus and Photorhabdus to characterise novel insect toxins
Reference
BBS/E/H/00032648
Principal Investigator / Supervisor
Dr James Morgan
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Warwick HRI
Funding type
Research
Value (£)
520,100
Status
Completed
Type
Institute Project
Start date
01/04/2003
End date
31/03/2005
Duration
24 months
Abstract
Strains of bacterial symbionts of insect parasitic nematodes produce proteinaceous toxins that are active against a range of important insects including key Lepidoptera, Coleoptera and aphids. The toxin genes in two Xenorhabdus strains have been identified. We have shown that three genes are required for full insecticidal activity, one protein (XptA like) is required for specificity (host range) while the other two proteins are required for enhanced activity (XptB and XptC like). The XptA like toxins interact with target cells independently of XptB and XptC; while XptB and XptC need to be present in the same cell for functional activity. This project has two main goals, to study the structure and function of the Xpt proteins, and to look at the genomic organisation of toxin genes in Xenorhabdus and Photorhabdus.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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