BBSRC Portfolio Analyser
Award details
Rational design of novel fungicides effective against plant pathogens
Reference
BBS/E/F/04330966
Principal Investigator / Supervisor
Dr Anthony Michael
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
10,930
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/10/1999
Duration
31 months
Abstract
This work aims to use a molecular biological approach to the rational design of new fungicides based on inhibition of fungal polyamine biosynthesis. Polyamine biosynthesis genes will be cloned from plant pathogenic fungi and their host plant. The cloning of the fungal biosynthetic ornithine and S-adenosylmethionine decarboxylase genes will be achieved by using degenerate oligonucleotides with the polymerase chain reaction. In plants, there is an additional biosynthetic gene, arginine decarboxylase, which will also be isolated using the same technique. These genes will be used to manipulate polyamine metabolism in the fungi as the basis for the development of a "smart" screen. Genes will also be expressed in E. coli so that purified proteins can be studied at the biochemical or structural level.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search