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Protein secretion in Aspergillus niger
Reference
BBS/E/F/04330896
Principal Investigator / Supervisor
Dr D Archer
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
11,399
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1999
Duration
30 months
Abstract
This project is to investigate the impact of glycosylation on the secretion of proteins by Aspergillus niger. Inhibition of glycosylation of secretory proteins has a direct effect on the transcription of genes that encode folding chaperones and foldases resident in the endoplasmic reticulum of A. niger. These effects will be studied in detail. The work will complement research in the University of Nottingham and IFR which is funded by the European Union to identify and overcome the bottlenecks to secretion of heterologous proteins by filamentous fungi.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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