Award details

TCS-TARGETS: Bacterial two-component systems as targets for the development of novel antibacterials and anti-infectives

Reference	BBS/E/F/04311142
Principal Investigator / Supervisor	Dr Jerry Wells
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	102,291
Status	Completed
Type	Institute Project
Start date	01/11/2000
End date	31/10/2003
Duration	36 months

Abstract

Microbial drug resistance imposes an increasing threat to human and animal health and the development of new drugs to control bacterial infections is therefore urgently needed. The overall objective of this project is to exploit a new class of bacterial targets called two-component systems (TCS) for the development of novel antibacterials and drugs that specifically target the mechanisms by which bacteria establish infection in the host. This objective will be achieved by targetting pan-European critical mass, expertise and support to understanding of the structure, function and biological diversity of these targets. By the end of the project we will expect to have selected appropriate targets and have developed selected assays for inhibitors of those targets that can be used for high throughput screening in the pharmaceutical industry

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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