Award details

Cell engineering in Lactococcus lactis

Reference	BBS/E/F/04300968
Principal Investigator / Supervisor	Professor Michael Gasson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	68,215
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/10/1999
Duration	31 months

Abstract

This project aims to optimise the performance of Lactococcus lactis as a cell factory for the production of existing and novel industrially relevant compounds. The project will use a multidisciplinary approach that combines physiology, biochemistry, biophysics and molecular genetics to understand, improve, model and manipulate metabolic flux And the biosynthesis of polysaccharides. Improvement of strain performance will be sought through the analysis of stress and environmental response and will be coupled to the metabolic engineering aspects of the project. A significant part of the research programme will be devoted to metabolic engineering of the glycolytic flux and will focus on pyruvate as the gateway to a variety of metabolic routes. The potential to develop L. lactis as a cell factory for the production of novel metabolites of industrial value will be exploited using alanine biosynthesis as a model system.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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