Award details

Health implications of natural non-nutrient antioxidants (polyphenols): bioavailability and colon carcinogenesis (POLYBIND)

Reference	BBS/E/F/04141010
Principal Investigator / Supervisor	Dr Ian Johnson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	248,180
Status	Completed
Type	Institute Project
Start date	01/01/2000
End date	31/12/2002
Duration	36 months

Abstract

Colon cancer kills approximately 75,000 Europeans per year, and even a modest reduction would significantly benefit the EU both socially and financially. Many studies show an effect of naturally-occurring dietary plant polyphenols (non-nutrient antioxidants) on carcinogenesis. There are large differences in consumption of amount and type of polyphenols between North and South with lower risks associated with the Mediterranean diet. The objectives are to answer the following questions: How are dietary polyphenols metabolised? How do polyphenols alter the rates of carcinogen metabolism? What are the mechanisms whereby polyphenols affect cell signalling involved in apoptosis and proliferation? How do polyphenols modulate early events of colon carcinogenesis? Tea, wine, onions, tomatoes, various berries, cocoa, and certain non-food plants will be used as sources of polyphenols

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search