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Mechanism of action and regulation of the antioxidant enzyme, phospholipid hydroperoxide glutathione peroxidase
Reference
BBS/E/F/04140949
Principal Investigator / Supervisor
Professor Gary Williamson
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
63,952
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1999
Duration
30 months
Abstract
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is an important endogenous antioxidant, which is regulated by dietary selenium and plays a vital role in protection of membranes from oxidative stress. The biochemical mechanism and relevance of the human enzyme will be examined. Other proteins will also be tested for PHGPx activity. The enzymic activity may play a role in maintenance of body oxidative status and in protection against chronic disease.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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