Award details

Mathematical modelling

Reference	BBS/E/F/04101386
Principal Investigator / Supervisor	Dr Jack Dainty
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	15,937
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2002
Duration	12 months

Abstract

Investigators in the field of stable isotope mineral research are often faced with two problems which require mathematical input: 1) What quantity of stable isotope label should be given to a volunteer to allow an accurate measurement of absorption and retention from the resulting biological samples? 2) How does one convert the sample mass spectrometer ratios to a value of absorption and retention? A computer program will be developed to help answer these questions. Its features will include: Calculation of quantity of labelled inorganic doses (oral and IV) for human volunteer experiments. User will enter expected precision of mass spectrometer ratios, time points to be sampled, isotopic spectrum of sources and matrix (e.g. plasma, urine or faeces) being investigated. Program will have built-in predictions for the following minerals: Copper, selenium, iron, zinc, calcium, magnesium and molybdenum. Calculation of fraction of stable isotope source present in each measured sample. Matrix algebra is used to solve the series of simultaneous equations involving the mass spec measurements and the isotopic spectrum of the sources. User will enter the mass spec ratios for each sample. Again, the following minerals will all be calculated: Copper, selenium, iron, zinc, calcium, magnesium and molybdenum

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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