Award details

Iron homeostasis

Reference	BBS/E/F/04101385
Principal Investigator / Supervisor	Professor Susan Jane Fairweather-Tait
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	118,846
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2002
Duration	12 months

Abstract

The balance between iron deficiency and overload is primarily achieved through changes in absorption in the mucosal cells of the small intestine. This project has two objectives (a) to elucidate the mechanisms that regulate iron transport across mucosal epithelial cells, and (b) to develop improved and more sensitive methods for studying iron absorption, for human studies. Both approaches will be used to address questions relating to the interactions between dietary sources of iron, the efficiency of uptake into the blood and iron 'status' within the body. The mechanistic work will be carried out using an in vitro Caco- 2 cell system, and the in vivo studies will be performed in human volunteers (normal healthy individuals and men with HFE mutations) using iron stable isotopes, mass spectrometry and mathematical modelling

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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