Award details

Tissue integrity

Reference	BBS/E/F/02308359
Principal Investigator / Supervisor	Dr Ian Johnson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	348,208
Status	Completed
Type	Institute Project
Start date	01/04/1998
End date	31/03/2001
Duration	36 months

Abstract

Intestinal epithelial cells transport nutrients to the circulation and provide a barrier between the interior milieu and the gut lumen. The colorectal epithelia are also prone to inflammation, and to carcinoma, which is the second most common cause of death from cancer in the UK. For these reasons the impact of diet on the physiology of the intestinal mucosa is a major strategic issue for public health research. Using recently developed techniques we will measure the rate and spatial localisation of mitosis and apoptosis in intact crypts from experimental animals, and from human subjects, and explore the effects of systemic, intraluminal and food-borne constituents on the relevant cellular signalling pathways in the mucosa. Having recently established that phytochemicals and certain other dietary constituents simultaneously modulate mitosis and apoptosis and suppress the induction of precancerous lesions in an animal model, the next steps are to extend our understanding of the cellular mechanisms involved in these phenomena, and to determine whether the same principles apply to human tissue. Cultured human colonic mucosa will be used as a methodological bridge to cross the species divide.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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