Award details

Bioavailability of dietary phytoestrogens in man

Reference	BBS/E/F/02307051
Principal Investigator / Supervisor	Dr Ian Johnson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	78,725
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

There is currently much interest in the role of dietary phytoestrogens in human health. Whilst there is much epidemiological evidence that such compounds are beneficial in protection against certain cancers (and mechanistic hypotheses can be derived to account for this role) there is - at the same time - concern because of the possible deleterious effects of dietary phytoestrogens on reproductive function. We intend to explore (i) the relative roles of the glycosides as found in the plant with that of the aglycones formed during processing, (ii) the site(s) and mechanism(s) of absorption with particular emphasis on the small intestine, (iii) the role, if any, of dietary agents known to affect membrane permeability and glucose transport on isoflavone absorption, and (iv) the pharmacokinetics of absorption in a human study. The project will further understanding of the bioactivity of the phytoestrogens

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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