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Influence of diet on the cellular physiology of the isolated human colorectal crypt

Reference	BBS/E/F/02307050
Principal Investigator / Supervisor	Dr Ian Johnson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	18,074
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

Forty percent of the 'healthy' population have colorectal polyps in late middle age, and are therefore at risk of developing bowel cancer. In this project we will test the hypothesis that the colorectal mucosa of such patients has a general 'field' abnormality of crypt cell proliferation which can be normalised by diet. The project will link IFR, UEA and the N&N Hospital, which has recently become a regional centre for the MRC/ICRF National Polyp Study. This development provides regular access to mucosa from healthy subjects for the first time. State of-the art imaging techniques at UEA will be used to link crypt cell proliferation and the spatial dynamics of calcium signalling events in isolated human crypts. We will also determine the response of the mucosa to endogenous growth factors, and to dietary constituents, comparing mucosa from normal subjects with that from polyp patients. The knowledge gained will be used to optimise dietary strategies to contro l the mucosal response to food.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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