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An investigation into the mechanisms underlying the modulation of intestinal cell proliferation and apoptosis by dietary long chain fatty acids

Reference	BBS/E/F/02300950
Principal Investigator / Supervisor	Dr Ian Johnson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	42,600
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1999
Duration	30 months

Abstract

In humans, consumption of fish oil has been shown to protect against colorectal cancer and to suppress abnormalities of cell turnover in the mucosa of the large intestine. Polyunsaturated fatty acids (PUFA) from fish oil also suppress mitosis and stimulate programmed cell death (apoptosis) in cultured tumour cells, but the mechanism is unknown. The purpose of this student project is to determine whether the effects of PUFA on cultured cells and intact mucosal crypts share a common mechanism. The central hypothesis is that incorporation of PUFA from fish oil increases the susceptibility of rapidly proliferating mucosal cells to oxidative stress, and that this triggers genes which lead to apoptosis and expulsion of mutated cells from the mucosa. The experimental strategy will be to search for evidence of similar patterns of gene expression and cellular response in the in vitro system and in the crypts of the colorectal mucosa in vivo.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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