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Effect of copper in the food chain on human health (FOODCUE)

ReferenceBBS/E/F/02300771
Principal Investigator / Supervisor Professor Susan Jane Fairweather-Tait
Co-Investigators /
Co-Supervisors
Institution Quadram Institute Bioscience
DepartmentQuadram Institute Bioscience Department
Funding typeResearch
Value (£) 94,415
StatusCompleted
TypeInstitute Project
Start date 01/04/1997
End date 30/06/1999
Duration27 months

Abstract

At present dietary requirements for copper are uncertain. In humans, low intakes of copper may be associated with metabolic perturbations related to cardiovascular health and a combination of a low copper intake and a high fructose intake may exacerbate these effects. In order to investigate copper metabolism, nine healthy male volunteers will participate in a dietary intervention study of longitudinal design. Whilst resident in a Human Nutrition Unit, they will be fed a medium (1.6mg/d) copper diet followed by a low (0.7mg/d) copper diet and during each dietary period blood samples will be analysed for indices of copper status (plasma copper, caeruloplasmin, erythrocyte Cu,Zn-SOD) and risk factors for cardiovascular disease (plasma lipoproteins, platelet aggregation). The interaction between copper and fructose will be examined at the end of each dietary treatment. A second study will investigate dietary factors which affect copper absorption from high copper foods labelled intrinsically or extrinsically with 65Cu. Absorption will be compared with a reference dose of copper and will be measured by either plasma albumin enrichment or by 65Cu faecal monitoring using a rare earth element non- absorbable marker eg. Holmium.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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