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Award details
Development of Lactococcus lactis as a food-compatible cell factory
Reference
BBS/E/F/02207048
Principal Investigator / Supervisor
Professor Michael Gasson
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
263,764
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2000
Duration
36 months
Abstract
The lactic acid bacteria have exceptional potential as cell factories for the production of a wide variety of food- related proteins, peptides and metabolites. Whilst some progress has been made towards this objective, there remains a need for significant further development. This project is to maintain the IFR skill base in the genetics of lactic acid bacteria and continue the development of Lactococcus lactis as a pre-eminent microorganism for food- related biotechnology. An improved and versatile gene manipulation toolkit will be developed that will underpin a wide variety of other projects. A system for peptide production based on characterized lactococcal bacteriocin biosynthesis genes will be developed. Metabolic engineering of pyruvate metabolism will be further developed. The cell surface protein CluA will be developed for heterologous protein presentation, contributing to the development of L. lactis for vaccine delivery.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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