Award details

Eurofan (Node 9 - Special metabolism: polyketide metabolism )

Reference	BBS/E/F/02200757
Principal Investigator / Supervisor	Professor Michael Schweizer
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	1,134
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/06/1998
Duration	15 months

Abstract

The aim of this EUROFAN project is to investigate the possible existence of gene products in Saccharomyces cerevisiae which are involved in the synthesis of polyketides. Polyketides which are generally secondary metabolites have important pharmaceutical applications. We intend to identify polyketide genes by analyzing the metabolites of yeast subjected to different growth media. We will also use in silico analysis to search the unknown open reading frames (ORFs) uncovered by the Yeast Genome Sequencing project to identify similarities with existing polyketide synthase (PKS) genes from various species. Disruptants of putative PKS will more than likely be generated as a result of the EUROFAN six pack analysis.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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