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Dietary & hormonal regulation of fatty acid synthase
Reference
BBS/E/F/02200744
Principal Investigator / Supervisor
Professor Michael Schweizer
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
136,300
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/1998
Duration
12 months
Abstract
The effect of diet, mediated via the hormone insulin on the main lipogenic gene, fatty acid synthase (FAS) from Rattus norvegicus, is being investigated. Insulin-responsive elements have been located within the promoter of the gene. The DNA/protein interactions of these defined cis-acting elements will be studied in detail using gel electrophoretic mobility shift assays, UV cross-linking and in vitro footprinting. The influence of hormones, other than insulin, on the expression of the rat FAS will be investigated using cell culture.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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