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In vivo screening in yeast for the anticarcinogenic effects of food component

Reference	BBS/E/F/02200735
Principal Investigator / Supervisor	Professor Michael Schweizer
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	31,430
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1998
Duration	18 months

Abstract

DNA repair is an important cellular defence mechanism against carcinogenesis. There is conservation of DNA repair mechanisms in yeast and humans. Therefore, yeast could provide a good model system to investigate the effect of food components on this molecular process. We plan to establish a simple colour test involving the introduction of an indicator plasmid into yeast strains carrying mutations in one or more of the DNA repair genes. Specifically, we would test constituents of fruit, vegetables, coffee and tea using the engineered yeast strains. We believe that this simple blue/white selection system in yeast will be a valuable contribution towards screening substances for their protective effects against carcinogenesis and mutation.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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