Award details

Use of recombinant techniques to produce improved antibody probes for application to food systems

Reference	BBS/E/F/02150854
Principal Investigator / Supervisor	Professor Mike Morgan
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	117,429
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/1999
Duration	24 months

Abstract

Antibodies are increasingly used as tools for investigating food systems. Areas susceptible to this approach include aspects of food safety and storage, studies of diet/health relationships, and investigations of raw material quality and processing. A limitation to such research (and subsequent technology interaction) can be the availability of antibodies (be they polyclonal or monoclonal in nature) of the most appropriate properties. The potential for using recombinant protein technology to generate rare and useful antibodies is undoubted. We will generate recombinant antibodies against haptenic food contaminants and components; pesticides, mycotoxins and inherent bioactives. We will seek to manipulate the properties of these antibodies in a directed manner in order to improve affinity and specificity. In order to carry out this research we will need to continue to develop strategies of screening and selection, and of the most effective route for mutagenesis. Subsequently we will apply the antibodies generated to characterisation of food systems, and seek technology interaction where appropriate. The research will advance understanding of ligand-protein interactions at a fundamental level, whilst providing benefit of a direct and practical nature to the food industry

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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