Award details

Diet & gene interactions: a molecular basis for inter- individual variations in enzyme induction by diet

Reference	BBS/E/F/02150776
Principal Investigator / Supervisor	Professor Gary Williamson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	62,374
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/12/1998
Duration	21 months

Abstract

Glutathione S-transferase (GST) and quinone reductase (QR) are diet-inducible enzymes which show considerable polymorphism in both the amount of enzyme in a tissue and in the inducibility. The molecular basis for this variation is not known. We aim to determine the molecular mechanisms of polymorphism of these enzymes to indicate the role of the most important factors: variations in genotype, variations in expression of the transcription factors responsible for induction, and environmental factors. The results will help to explain the role of GST and QR polymorphisms in susceptibility to long term diseases and also indicate how diet can modify this susceptibility. The project will explore the possibility of giving individual dietary advice based on the genetic profile of individuals

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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