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Can diet mediated oxdidative stress selectively induce apoptosis in precancerous cells?

Reference	BBS/E/F/02100856
Principal Investigator / Supervisor	Dr A Pinder
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	83,910
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/1999
Duration	24 months

Abstract

This project is designed to address the hypothesis that, compared to normal cells, malignant cells are more susceptible to apoptotic cell death in response to low levels of diet related oxidative stress. The hypothesis is derived from a number of observations: (i) a low level of oxidative stress is essential for normal early growth of organisms; (ii) long chain fatty acids, which are known to increase oxidative stress when incorporated into cells, increase the incidence of apoptosis in cultured colon tumour cell lines; and (iii) a recent study from Finland showed that smokers given anti-oxidant vitamins had an increased risk of lung cancer. This question can be ideally addressed by the combination of expertise available in the Institute. The skills and knowledge base for studying colon cell proliferation and apoptosis already exist in the Intestinal Growth and Function Group, while the Quantum Biophysics Group contributes much experience in flow cytometry which is a sensitive and powerful method for quantifying the early expression of proteins associated with cell proliferation and cell death and the stages of DNA breakdown.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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