Award details

Modulation of the gut microbes to promote health throughout life

Reference	BBS/E/F/000PR10356
Principal Investigator / Supervisor	Professor Arjan Narbad
Co-Investigators / Co-Supervisors	Dr Evelien Adriaenssens, Professor Simon Carding, Professor Lindsay Jennifer Hall, Professor Nathalie Juge, Professor Stella Knight, Professor Tom Wileman
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	4,647,497
Status	Current
Type	Institute Project
Start date	01/04/2018
End date	31/03/2023
Duration	47 months

Abstract

This theme focuses on the translational aspect of the Gut Microbes and Health programme, which will pursue ongoing applied work within the programme but will also identify additional targets based on the output of basic research outlined in themes 1 and 2, to strengthen and further develop strategies to promote health throughout life. Specifically, these will focus on developing bifidobacterial-based probiotics for infant supplements as well as lactic acid bacteria for animal feed to reduce the pathogen load in the food chain to reduce the incidents of food poisoning in humans. Gut commensal organisms capable of efficient expression of specific enzyme and antimicrobial peptides to inhibit pathogens such as C. difficile, which affects the elderly, will be developed and tested. We also propose to identify carbohydrate-based mucosal barrier protectors as well as gut commensals and their products as therapeutics and for development of vaccines to promote gut health. We will explore strategies for modulation of the structure and function of the gut microbiome, including the application of faecal microbiota transplant, phage therapy and exploitation of the gut commensal eukaryotes (yeast and fungi) for restoration of gut microbiota homeostasis. We will utilise in-house facilities of tissue and organ cultures, in vitro colon models, animal models (including germ free mice) as well as human intervention studies to conduct proof-of-concept studies and demonstrate efficacy of the strategies developed.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Immunology, Microbial Food Safety, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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