Award details

Markers of systemic and mucosal inflammation as biomarkers of vulnerability to colorectal cancer

Reference	BBS/E/F/00052095
Principal Investigator / Supervisor	Dr Ian Johnson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	4,771
Status	Completed
Type	Institute Project
Start date	01/10/2005
End date	31/10/2007
Duration	25 months

Abstract

This project will test the hypothesis that systemic inflammation (associated with high body-weight and adiposity) is causally linked with low-grade colorectal mucosal inflammation, and that this condition is associated with higher vulnerability to colorectal neoplasia. If the hypothesis is confirmed, plasma and faecal markers of inflammation may be useable as surrogate biomarkers of early neoplasia. We will recruit 100 healthy controls and 100 patients with a history of polyps. Each volunteer will provide anthropometric data and samples of blood and faeces. We will measure C-reactive protein as a systemic marker of inflammation and faecal calprotectin, lactoferrin and IL-6 as markers of colorectal inflammation. Using multivariate techniques we will search for evidence of associations in the two groups.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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