Award details

Selenium status and immune function

Reference	BBS/E/F/00051949
Principal Investigator / Supervisor	Dr Charlotte Armah
Co-Investigators / Co-Supervisors	Dr David Hughes
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	45,132
Status	Completed
Type	Institute Project
Start date	01/01/2005
End date	31/08/2008
Duration	44 months

Abstract

The aim of this FSA funded project is to investigate the relationship between dose and form of Se and immune function, and to identify functional markers of Se status. Healthy adults (50-64y) with low habitual intakes of Se identified from plasma Se concentration (<1.2mu-mol/L; <95mu-g/L) will be allocated to one of 6 groups (n=24 per group) in a 12 week intervention with the following treatments: (1) 50mu-g/d Se (SeMet) (2) 100mu-g/d Se (SeMet) (3) 150mu-g Se (SeMet) (4) Se-enriched onions (50mu-g/d, mainly SeMC) (5) unenriched onions (6) no dietary intervention. Changes in the expression of Se-responsive genes (RT-PCR) and proteins in blood will be measured and compared with changes in plasma Se concentration and selected selenoproteins. The relationship between dietary Se intake and systemic and mucosal immune responses to influenza vaccine will be examined. Changes in immune cell populations and the influence of Se on NK and CD8 cytotoxicity will be determined by flow cytometry; NF-/B expression, an index of immunological function, will be assessed using an antibody-based method.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Ageing, Diet and Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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