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Validation of novel diet-related biomarkers of early colorectal neoplasia-use of proteomic technology & identification of mitochondrial DNA mutations

Reference	BBS/E/F/00051938
Principal Investigator / Supervisor	Dr Ian Johnson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	21,548
Status	Completed
Type	Institute Project
Start date	01/04/2005
End date	31/03/2009
Duration	48 months

Abstract

Understanding the roles played by dietary factors in the development or prevention of bowel cancer is hampered by the lack of robust surrogate endpoints that have been demonstrated to be diet-related. Identification of such biomarkers of preclinical colorectal neoplasia is essential in order to provide the basis for both screening studies, and for dietary intervention studies to reduce the burden of bowel cancer. The objectives of this project are: 1. To recruit 200 healthy volunteers who will provide colo-rectal biopsies, blood and buccal cells, and data with which to characterise their dietary and other lifestyle exposure. 2. To quantify i) gene expression patterns in colorectal mucosa using state-of-the-art proteomics methods, ii) mitochondrial DNA mutations in colonic epithelia and iii) other biomarkers including DNA damage. 3. To use statistical methods to determine the relationships between habitual diet and nutritional status and novel biomarkers of mucosa vulnerability to cancer. 4. To assess the utility of buccal cells as possible surrogate tissues for colorectal mucosa.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Ageing, Diet and Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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