Award details

Gut Systems Biology, connecting microbes and host processes

Reference	BBS/E/F/00044500
Principal Investigator / Supervisor	Dr Tamas Korcsmaros
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	160,708
Status	Current
Type	Institute Project
Start date	01/04/2014
End date	31/03/2018
Duration	47 months

Abstract

The Korcsmaros group under this project applies network biology to analyse experimental data, develop in silico predictions and validate them with small-scale or large-scale (omics) approaches. The biological focus in this project is autophagy, gut microbes (both commensals and pathogens) that could affect the host’s autophagy process, and disease states such as IBD. The project also involves developing novel experimental protocols to measure autophagy upon infection and in organoids. The project involves a post-doc research assistant and supported by PhD students (co-)supervised by T. Korcsmaros. The project is closely connected and complement IFR projects of the Carding, Hall and Baranyi group as well as Tom Wileman’s work at the UEA. Major objectives of the project are: 1) reconstructing molecular interaction networks for gut microbes and intestinal epithelial cell specific host cells; 2) develop host-microbe interaction maps; 3) perform experiments for validation of the predictions; 4) develop new experimental approaches to measure autophagy.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Microbiology, Systems Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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