Award details

Gut commensals: interaction with the host and analysis of their role in health and disease

Reference	BBS/E/F/00044453
Principal Investigator / Supervisor	Professor Arjan Narbad
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	2,165,315
Status	Current
Type	Institute Project
Start date	01/04/2010
End date	31/03/2018
Duration	95 months

Abstract

The human GI tract contains a complex array of microbes with more than 1000 bacterial species. We now know that the gut microbiota plays a critical role in the maintenance of gut health in both humans and animals. In this project we will use the culture independent molecular profiling methods to analyse the gut bacteria and isolate key strains that are either protective against gut pathogens or have a proinflammatory properties in the human GI tract. We will focus on the functional characterisation of a model probiotic strain of Lactobacillus johnsonii that has been identified as competitive excluder of human gut pathogens in the GI tract of farm animals. We will undertake transcriptomics, proteomics and molecular genetic studies to identify the mechanisms of competitive exclusion process. Detailed ecological studies and the role of Sulphate Reducing bacteria in the development gut disorders will be assessed and the molecular studies of the key strains of Desulphovibrio piger will be performed both in vivo and in vitro colon model systems to study the interactions between the gut commensal bacteria.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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