Award details

Career Progression Fellow

Reference	BBS/E/F/00044406
Principal Investigator / Supervisor	Dr Maria Pin Arias
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	937,403
Status	Current
Type	Institute Project
Start date	01/04/2010
End date	31/03/2018
Duration	95 months

Abstract

The mucosa of the gastrointestinal (GI) tract forms a major organ for the absorption of nutritional compounds from the intestinal lumen and for the defence against pathogenic agents. The main elements specific to the GI tract are the epithelium, the immune structures and the bacteria. The large intestine houses hundreds of species of commensal bacteria that provide a number of benefits to the host, including protection from pathogenic transients, nutritional benefits and maturation of mucosal immunity. We are targeting to understand the interactions between pathogenic and commensal bacteria taken place in the gut previous to infection. Modelling bacterial interactions is targeted at the molecular level by integrating transcriptomics, metabolomics and genomic population analysis. This involves an increase of complexity in the modelling approaches required to describe the mechanisms of interactions between bacterial populations taken place in the GI tract.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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