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BBSRC Studentship: Bioavailability and biological activity of sulphur-containing bioactive compounds from broccoli

Reference	BBS/E/F/00042709
Principal Investigator / Supervisor	Professor Richard Mithen
Co-Investigators / Co-Supervisors	Dr Maria Traka
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	3,033
Status	Current
Type	Institute Project
Start date	01/10/2013
End date	30/09/2017
Duration	47 months

Abstract

The Mithen research group at IFR have developed a series of near-isogenic broccoli genotypes with varying levels of 4-methylsulphinylbutyl glucosinolate (glucoraphanin) due to allelic variation at the Myb28 locus. These broccoli genotypes have been processed into soups and are being used as part of a long term dietary intervention study. This project is concerned with a detailed analyses of sulphur-metabolites found in human plasma and urine following consumption of these soups. It involves a three arm doubled blinded cross over study with ten volunteers. Each arm consists of consuming a single 300 ml portion of soup made from one of three broccoli genotypes of different Myb28 genotypes. Blood and urine samples are collected over the 48 hours following consumption for analysis of a range of sulphur-containing metabolites derived from glucoraphanin. The human study is complemented with exploring the biological activity of these S metabolites particularly regarding their ability to enhance expression of genes of the pentose phosphate pathway in human liver cells.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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