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BBSRC Studentship: The importance of eosinophil-epithelial stem cell interactions for the maintenance of the human colonic mucosa

Reference	BBS/E/F/00042708
Principal Investigator / Supervisor	Dr Anastasia Sobolewski
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	2,135
Status	Completed
Type	Institute Project
Start date	01/10/2013
End date	31/12/2015
Duration	26 months

Abstract

The intestinal epithelium forms a barrier between commensal bacteria and the underlying lamina propria immune cells. The colonic epithelium constantly renews itself through proliferation epithelial stem cells located at the base of epithelial invaginations called crypts. Work from our laboratory and others have shown that shown that immune cells are recruited to the epithelial stem cell niche following sensing of commensal bacteria during homeostasis (unpublished) and injury (Pull et al. 2007 PNAS). Eosinophils reside at the crypt stem cell niche in the lamina propria of the healthy colon and can secrete either pro- or anti-inflammatory factors (Lee et al. 2010 Clin Exp. Allergy). The molecular and cellular mechanisms by which the epithelial stem cell niche either modulates, and/or is modulated by, immune cells to maintain epithelial homeostasis are largely unknown. This project will determine the nature of the interaction between eosinophils (and their secreted factors)and crypt stem cells during homeostasis. Specific objectives of this study are to: -characterise the effects of the colonic epithelium on eosinophil cell death/survival - investigate the effect of eosinophils on epithelial proliferation and renewal -investigate of the effect of E.coli stimulation on the mobilisation of eosinophils to the epithelial stem cell niche in a human organ culture model

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Immunology, Microbiology, Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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