Award details

Analysis of the gut microbiota composition in neonates after probiotic treatment

Reference	BBS/E/F/00042701
Principal Investigator / Supervisor	Professor Lindsay Jennifer Hall
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	18,988
Status	Current
Type	Institute Project
Start date	01/03/2013
End date	31/08/2016
Duration	41 months

Abstract

We are born completely sterile, but soon become colonised by complex microbial communities that shapes our immune defence for life. Disturbances in early colonisation events, such as premature delivery, can lead to an increased risk of developing serious life-threatening bacterial infections, such as necrotising enterocolitis (NEC). The process of initial gut microbial colonisation in preterm babies is radically interrupted due to a variety of factors (e.g. mode of delivery and antibiotics). Manipulation of our gut microbial communities by probiotic strategies has the potential to ‘correct’ any microbial disturbances. Before these treatments can be used in UK-wide routine neonatal care, we require an improved understanding about how these probiotic bacteria alter the composition of the neonatal gut microbial communities. This UEA grant will (i) characterise preterm vs. preterm probiotic-treated vs. healthy gut microbiota community of neonates and (ii) define and characterise individual components of the neonatal human microbiota using culture and whole genome sequencing to identify potential new probiotics strategies.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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