Award details

Development of the Dynamic Gastric Model

Reference	BBS/E/F/00042689
Principal Investigator / Supervisor	Professor Peter Wilde
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	201,879
Status	Completed
Type	Institute Project
Start date	01/03/2013
End date	27/08/2015
Duration	29 months

Abstract

FoodPro ForHealth will develop strategies to formulate and process foods to control lipid digestion; it will combine the Fellow’s food science skills with expertise and techniques at the Institute of Food Research (IFR) in the colloids, interfacial, model gut and health areas. The Dynamic Gastric Model (DGM) is an advanced model of human gastric digestion. It is the only model currently available which accurately simulates the physical and biochemical environment of the human stomach in a real time simulation. It is designed to predict the availability for uptake (bioaccessibility) of active components such as nutrients and drugs, it requires further studies to validate its ability to predict the bioavailability of bioactive molecules. We will provide a thorough and convincing dataset that will validate the DGM for the in-vitro characterization and predictive modelling of pharmaceutical dose form performance. In-vivo datasets for uptake will be gathered from collaborating pharmaceutical companies. Specific areas of human clinical research are not amenable due to ethical concerns. In adults, abuse of alcohol or taking drugs or nutritional supplements in combination with prescription drugs may alter drug exposure. Similarly, clinical trials on healthy infants have ethical concerns. With minor modifications, the DGM can provide valuable predictive data which can then be used for future, targeted human studies where possible, or to provide appropriate warning information to doctors and patients regarding potential risks. Further developments in the model will be devised to simulate different age states. Existing knowledge will be used to improve and simplify the current DGM. Modifications will be made to develop a simplified, flexible and commercially viable next generation device. The DGM technology has considerable commercial potential as specialised equipment for research and development arenas. We will engage manufacturers to negotiate the production and distribution of the DGM, and its associated peripheral products. We will also seek to transfer the contract research unit, built around the DGM into a Contract Research Organisation to increase access to Model Gut services to the food and pharmaceutical industries.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search