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Epigenetics and Nutrition: DNA Methylation, Dietary Intake, and Cardiovascular Disease

Reference	BBS/E/F/00042645
Principal Investigator / Supervisor	Dr Nigel Belshaw
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	110,000
Status	Completed
Type	Institute Project
Start date	02/08/2011
End date	31/05/2014
Duration	34 months

Abstract

DNA methylation represents a gene regulatory mechanism affected by environmental exposures that may be implicated in complex diseases with both genetic and environmental components. Recent evidence suggests that aberrant DNA methylation occurs during aging in a concept known as “epigenetic drift”. This mechanism and its modulation by environmental factors such as diet, may promote the development of chronic diseases including cardiovascular disease (CVD). This study brings together multidisciplinary expertise for a collaborative effort to investigate associations between nutrition, DNA methylation and cardiovascular disease in a well-characterized epidemiologic cohort of older adults, the Cardiovascular Health Study (CHS). The study will explore the hypothesis that dietary factors modulate the methylation of specific genes thereby contributing to the risk of cardiovascular disease. We will utilize DNA and data collected in the CHS, a large NHLBI-sponsored observational cohort of adults age 65 years and older to investigate the dynamics of DNA methylation in relation to CVD with a focus on nutrition as a mediator in the relationship.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Ageing, Diet and Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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