Award details

BBSRC Studentship: Reciprocal control and regulation of key immunological events in the intestine

Reference	BBS/E/F/00042636
Principal Investigator / Supervisor	Dr Claudio Nicoletti
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	7,040
Status	Completed
Type	Institute Project
Start date	01/10/2011
End date	30/09/2015
Duration	47 months

Abstract

Aim of this project is to dissect in details regulatory pathways that play a role in maintaining and restoring the correct intestinal immune homeostasis. In previous experiments we have observed that the reciprocal regulation of certain cytokines, such as IL-12 and TSLP is critical to maintain the immunological balance. An important aspect of this project is the development of human model to investigate aspects of mucosal immunity. To this end, we are collaborating with the Norfolk and Norwich Univ Hospital for the collection of human biopsies to establish a medium term in vitro organ culture. The human model will enable us to monitor global gene expression in the human gut immune system and to carry out experiments involving gene silencing and suppression to identify specific immunological pathways in various conditions including responses to food components and pathogens.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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