Award details

BBSRC Studentship: Broccoli, insulin signalling and the prevention of prostate cancer

Reference	BBS/E/F/00042604
Principal Investigator / Supervisor	Professor Richard Mithen
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	3,000
Status	Completed
Type	Institute Project
Start date	01/10/2010
End date	30/09/2014
Duration	48 months

Abstract

Isothiocyanates are a well-studied group of phytochemicals that are present at high levels in cruciferous vegetables. They have a wide range of functions which enable them to exert anti-inflammatory and anti-cancer effects. Chronic diseases such as cancer, type 2 diabetes and cardiovascular disease are often linked to obesity and diet. The main aim of this project is to investigate the signalling pathways and mechanisms by which this group of phytochemicals may be able to affect the risk and development of these diseases. This will be via a number of experimental designs and methods, using in vitro cell culture and ex vivo models to look at the effects of treatments on inflammatory biomarkers, in particular, Interleukin-6, using ELISA techniques, while the mechanistic details will be investigated using flow cytometry. In addition, an in vivo study in a mouse model of diet-induced obesity will be used to look at how dietary intervention with this group of compounds can affect its inflammatory status, and subsequent development of disease.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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