Award details

BBSRC Studentship: Functional modulation of the intestinal mucas layer by commensal bacteria

Reference	BBS/E/F/00042562
Principal Investigator / Supervisor	Professor Nathalie Juge
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	5,900
Status	Completed
Type	Institute Project
Start date	01/10/2009
End date	22/11/2013
Duration	49 months

Abstract

Intestinal tract mucins are principal components of the intestinal mucosa and perform a protective function against microbial and mechanical damage. By directly modulating gene expression in the epithelium the microbiota can affect several physiological processes of the intestinal tract. The project uses an interdisciplinary approach to i) investigate whether bacteria residing in the gut regulate mucin expression and glycosylation, and ii) evaluate the consequence of mucin alteration on intestinal immune responses. The knowledge generated by the project will help develop strategies to treat intestinal pathologies affecting the mucus barrier. The specific objectives of the project are: Objective 1: Set up and characterisation of mouse IEC models Objective 2: Functional modulation of mucus expression in response to gut bacteria Objective 3: Functional modulation of mucin glycosylation in response to gut bacteria Objective 4: Functional consequences of mucus deficiency and altered mucin expression on IEC responses to gut bacteria The work will be carried out in the Gastrointestinal Tract (GIT) Programme, which is engaged in elucidating the specificity of gut-microbe interactions. The project is supervised by Dr Nathalie Juge (IFR-GIT) and Prof Simon Carding (IFR-GIT and UEA).

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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