Award details

The Role of Plant Cell Walls in Regulating Starch and Lipid Bioaccessibility from Plant Foods: In Silico, In Vitro and In Vivo Studies

Reference	BBS/E/F/00042558
Principal Investigator / Supervisor	Professor Keith Waldron
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	86,200
Status	Completed
Type	Institute Project
Start date	19/04/2010
End date	18/06/2014
Duration	50 months

Abstract

The project has the following objectives: 1. Characterise raw, processed and masticated plant foods rich in lipid and starch. 2. Establish that lipase and amylase penetrate plant cell walls and hydrolyse intra-cellular lipid and starch, respectively. 3. Determine the rate and extent of lipid and starch digestion of plant foods in vitro and in vivo 4. Develop a mathematical model for predicting bioaccessibility of lipid and starch. 5. Identify the mechanisms by which plant cell walls (PCW) influence nutrient release and digestion kinetics. The Model Gut (MG) and Sustainability of the Food Chain (SFC) Exploitation Platforms will be working predominantly on objectives 1 and 3, with some input on objectives 2, 4 and 5. Objective 1 (Jan – Jun 2011): Characterise the cell walls of raw, processed and masticated plant foods. (SFC) Objective 2 (Apr 2011 – Oct 2012): Assist in producing separated cells from almonds, cereals and legumes (SFC). These will be used at KCL. Objective 3 (Jan 2011 – Jul 2013): Determine the rate and extent of lipid and starch digestion of plant foods using the DGM and static duodenal digestion model (MG). The effects of digestion by the DGM will be compared to those from digestion by ileostomy patients to validate the DGM. Characterise digested plant foods (SFC). Objective 4 (Jan – Oct 2013): Develop a mathematical model for predicting bioaccessibility of lipid and starch (KCL). The DGM experiments will provide the data on digestion of plant foods to develop the mathematical model. Objective 5 (Jan – Oct 2013): Identify the mechanisms by which PCW influence nutrient release and digestion kinetics. All collaborators will be involved in the final analysis of the results and submission of the resulting publications by Oct 2013.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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