Award details

Towards Safe and Effective Immunotherapy of Persistent Life-Threatening Food Allergies

Reference	BBS/E/F/00042515
Principal Investigator / Supervisor	Dr Claudio Nicoletti
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	178,600
Status	Current
Type	Institute Project
Start date	01/09/2008
End date	30/08/2015
Duration	83 months

Abstract

This collaborative project brings together clinicians, immunologists and biochemists from 15 centres, including 4 industrial partners, to develop specific immunotherapy for food allergy. This approach currently offers the only opportunity to provide food allergic individuals with a cure. The study is focussed on two foods, fish and peach and will develop hypoallergenic mutants of the major allergens in these foods, namely fish parvalbumin and peach lipid transfer protein (LTP). The mutants will be produced either by heterologous expression and initially their efficacy for immunotherapy will be assessed using animal models. Mutants that pass this initial phase will then enter into clinical studies to evaluate their efficacy in man. IFR is involved in the initial stages with Dr Clare Mills evaluating the hypoallergenic variants from a structural view point whilst Professor Claudio Nicoletti is undertaking animal model studies to assess the efficacy of the peach LTP mutants.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Diet and Health, Immunology, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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