Award details

Development of recombinant LAB for the treatment of Food Allergy Disease by targetting intestinal Dendritic Cells (LABANDEN)

Reference	BBS/E/F/00042363
Principal Investigator / Supervisor	Professor Arjan Narbad
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	12,500
Status	Completed
Type	Institute Project
Start date	01/09/2007
End date	28/02/2010
Duration	30 months

Abstract

The prevalence of common allergic diseases has trebled in the last twenty years, resulting in approximately one-fifth of the EU population likely to require treatment for an allergy. It is estimated that around 1-2% of adults and between 5-7% of children suffer from some type of food allergy, and it is increasing in the Western world. The Aim of this project is to examine a possible additive or synergistic effect of using recombinant lactic acid bacteria strains producing IL-12, which will regulate the intestinal dendritic cells (DCs) in a food allergy condition at the initial onset period of the illness. This project will develop a potential treatment for reducing or eliminating allergy symptoms as a response to an increasing rate of food allergy in the EU. Lactic acid bacteria (LAB) which have a long and safe history of use in food fermentation products will be engineered to produce high levels of IL-12. Using an allergy model system the recombinant LAB strains will be used to deliver the cytokine at the mucosal surface in order to check the possible regulation of Th1 response at gastrointestinal DCs level.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Diet and Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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