Award details

Comparative proteomics

Reference	BBS/E/F/00042291
Principal Investigator / Supervisor	Dr Francis Mulholland
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	267,181
Status	Completed
Type	Institute Project
Start date	01/04/2005
End date	01/04/2009
Duration	48 months

Abstract

The development of proteomics for the analysis of changes to the proteome under different physiological and environmental conditions in bacteria, humans and plants is core to many of the advanced scietific activities of the Institute. In particular, Campylobacter, human cell lines and plants are key systems that are being studied by comparative proteomics. In addition to detecting proteins that change in abundance, a key goal is to characterise the nature of post-translational modifications. This technology is clearly key to most genomics-based projects and underpins the Institute's System Biology activities. It is our intention to develop a flagship project using Campylobacter as the model, where transcriptomic, proteomic and metabolomic analyses will be performed in parallel and an important effort will be made to integrate the results from each technology to determine how information feeds down from the transcriptome to the proteome and thereby affects the metabolome. A similar project will be developed for Arabidopsis as a model, in collaboration with the JIC, leading to joint grant proposals in this area.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	Animal Health, Microbial Food Safety, Microbiology, Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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