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Award details
Cellular and molecular basis of food allergy
Reference
BBS/E/F/00042272
Principal Investigator / Supervisor
Dr Claudio Nicoletti
Co-Investigators /
Co-Supervisors
Professor Michael Gasson
,
Dr Ian Johnson
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
981,608
Status
Completed
Type
Institute Project
Start date
01/04/2005
End date
31/03/2010
Duration
60 months
Abstract
We will study cellular and molecular events that play a role in the sensitization process to foods components using a combination of animal and human models. Part of the work will focus on the role of gut epithelium in the genesis of adverse reactions to foods. In particular, we are interested in addressing the role of intestinal epithelial cells (IEC) from allergic subjects in the regulation of intestinal immune homeostasis. Furthermore, extending our previous studies, we will continue to investigate the role of both gut and systemic dendritic cells (DCs) in food allergy. The ultimate goal is to provide useful information to devise novel strategies of therapeutic intervention in food allergy.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
Diet and Health, Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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