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Investigating the diversity and role of carbohydrate-active proteins/enzymes in human gut microbiota
Reference
BBS/E/F/00042268
Principal Investigator / Supervisor
Professor Nathalie Juge
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
622,200
Status
Completed
Type
Institute Project
Start date
01/06/2007
End date
31/03/2010
Duration
34 months
Abstract
The aim of the research is to exploit recent developments in human (meta) genomics to explore the diversity and specificity of enzymes and proteins involved in carbohydrate metabolism in the human gut. Approaches including functional and comparative genomics, metabolomics and gnotobiotic mouse models will be used to study the molecular events underlying the adaptation of gut bacteria to diet and the effect on host response. This is complemented by detailed molecular enzymology and structural studies of human gut glycoside hydrolases and binding modules involved in hydrolysis of complex polysaccharides.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
Diet and Health, Microbiology, Structural Biology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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