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The regulation of intestinal epithelial barrier function

Reference	BBS/E/F/00042243
Principal Investigator / Supervisor	Professor Simon Carding
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	130,200
Status	Completed
Type	Institute Project
Start date	01/04/2009
End date	31/03/2010
Duration	12 months

Abstract

How epithelial cells prevent pathogen invasion and inflammation in the intestine is being investigated. Animal models of gut inflammation and infection are being used to identify how epithelial cells communicate with mucosal immune cells to initiate responses to pathogens and inflammatory stimuli in the gut. We are also using the parasite Toxoplasma gondii to study how pathogens cross the epithelial barrier and can disrupt the tight junctions that glue adjacent epithelial cells together.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Diet and Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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