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Innate immunity maintains stem cell-driven renewal of the intestinal epithelium

Reference	BBS/E/F/00042234
Principal Investigator / Supervisor	Dr Anastasia Sobolewski
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	112,600
Status	Completed
Type	Institute Project
Start date	01/04/2009
End date	31/03/2010
Duration	12 months

Abstract

How bacteria and mucosal immune cells maintain the renewal of the epithelial barrier of the intestine is being is being investigated. In particular, how immune cells detect bacteria or inflammatory stimuli at the luminal surface and in some way relocate to the stem cell niche to regulate epithelial renewal. Bio-imaging of in vivo fluorescent transgenic mouse models and ex vivo culture systems, such as microbial-epithelial crypt co-culture, is being used to address how a healthy gut is maintained.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Diet and Health, Immunology, Microbiology, Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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