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Molecular microbiology of commensal lactic acid bacteria
Reference
BBS/E/F/00042218
Principal Investigator / Supervisor
Dr Claire Shearman
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
768,057
Status
Completed
Type
Institute Project
Start date
01/04/2005
End date
01/04/2009
Duration
48 months
Abstract
This project builds on established expertise in the molecular genetics of lactic acid bacteria. With a recently completed whole genome sequence Lactococcus lactis MG1363, a DNA microarray will be constructed and used in functional genomics analysis of genome structure, gene transfer systems and metabolism. The metabolic simplicity and availability of an advanced genetic toolbox make this lactococcal system advantageous as a generic model for investigation of genomic plasticity and consequences of metabolic perturbation. Fundamental molecular microbiology will be extended to Lactobacillus strains with demonstrated ability to compete with pathogens, and Bifidobacterium species associated with positive health status in the gastrointestinal tract.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
Diet and Health, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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