BBSRC Portfolio Analyser

Award details

Validation of a food frequency questionnaire to measure the dietary intake of flavonoids against urinary flavonoids

ReferenceBBS/E/F/00042150
Principal Investigator / Supervisor Dr Ian Johnson
Co-Investigators /
Co-Supervisors
Institution Quadram Institute Bioscience
DepartmentQuadram Institute Bioscience Department
Funding typeResearch
Value (£) 3,989
StatusCompleted
TypeInstitute Project
Start date 01/05/2005
End date 31/12/2005
Duration8 months

Abstract

Dietary flavonoids may protect against the development of cancers of the gastro-intestinal tract. There is epidemiological evidence that antioxidants have a protective effect of up to 40-50 % against oesophageal cancer. Flavonoids are found ubiquitously in the diet and have potential anticarcinogenic properties including antioxidant, cyclo-oxygenase & lipo-oxygenase enzyme inhibiting action. They are present mainly in citrus fruits, vegetables, tea, and wine. Quercetin is the most commonly studied flavonoid and is easily detectable in the urine up to 24 hrs after ingestion. Food frequency questionnaires (FFQ) are used to measure habitual diet over a specified time period. However, currently there are limited studies, which have validated a FFQ on fruits and vegetable intake against urinary flavonoids. A validated FFQ for total dietary flavonoid intake as measured against urinary markers in a United Kingdom population is required. In this study, subjects will complete a single FFQ and provide two 24 hour urinary samples to measure the flavonoid excretion for which a correlation coefficient will be calculated for dietary intake against urinary excretion. A validated FFQ could then be used in case-control studies investigating if dietary flavonoids protect against cancer such as oesophageal cancer.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
terms and conditions of use (opens in new window)
export PDF file
back to list new search